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Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Koreaopen access
- Authors
- Shin, Jeong Hwan; Jung, Hee Jung; Kim, Hye Ran; Jeong, Joseph; Jeong, Seok Hoon; Kim, Sunjoo; Lee, Eun Yup; Lee, Jeong Nyeo; Chang, Chulhun Ludgerus
- Issue Date
- Jul-2007
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, v.51, no.7, pp 2625 - 2627
- Pages
- 3
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Volume
- 51
- Number
- 7
- Start Page
- 2625
- End Page
- 2627
- ISSN
- 0066-4804
1098-6596
- Abstract
- The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.
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