Streptozotocin-induced diabetes decreases placenta growth factor (PIGF) levels in rat placenta
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Phil-Ok | - |
dc.contributor.author | Sung, Jin-Hee | - |
dc.contributor.author | Won, Chung-Kil | - |
dc.contributor.author | Cho, Jae-Hyeun | - |
dc.contributor.author | Moon, Jong-Gon | - |
dc.contributor.author | Park, Oh-Sung | - |
dc.contributor.author | Kim, Myeong-Ok | - |
dc.date.accessioned | 2022-12-27T06:53:16Z | - |
dc.date.available | 2022-12-27T06:53:16Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2007-09 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/28297 | - |
dc.description.abstract | The placenta produces several growth factors, including placenta growth factor (PIGF), which are essential for placenta growth and fetal growth. Diabetic pregnancy induces the abnormal placental growth and fetal development. This study investigated whether diabetes in pregnant rats induces changes in PIGF expression in the placenta. Diabetes was induced by a single intravenous injection of streptozotocin (35 mg/kg body weight) on day 0 of pregnancy, blood and tissue samples were collected on day 20 of pregnancy. In the diabetic group, maternal body weight and fetal weight significantly decreased compared to controls. RT-PCR and Western blot analyses showed that expression of PlGF was significantly decreased in placenta by streptozotocin treatment. Immunohistochemical study showed that the positive signal of PIGF in trophoblast cells was decreased in the diabetic group compared to controls. These findings demonstrate the decline of PIGF in the placenta in diabetic pregnancy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN SOC VET SCI | - |
dc.subject | EXPRESSION | - |
dc.subject | TROPHOBLAST | - |
dc.subject | PREGNANCY | - |
dc.subject | APOPTOSIS | - |
dc.subject | FETAL | - |
dc.subject | IDENTIFICATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | VILLI | - |
dc.subject | GENE | - |
dc.title | Streptozotocin-induced diabetes decreases placenta growth factor (PIGF) levels in rat placenta | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Phil-Ok | - |
dc.contributor.affiliatedAuthor | Won, Chung-Kil | - |
dc.contributor.affiliatedAuthor | Kim, Myeong-Ok | - |
dc.identifier.doi | 10.1292/jvms.69.877 | - |
dc.identifier.scopusid | 2-s2.0-34548684469 | - |
dc.identifier.wosid | 000250117300001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, v.69, no.9, pp.877 - 880 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.volume | 69 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 877 | - |
dc.citation.endPage | 880 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TROPHOBLAST | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | FETAL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | VILLI | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | placenta | - |
dc.subject.keywordAuthor | PIGF | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.