Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Jang, Hong Seok | - |
dc.contributor.author | Kang, Ki Mun | - |
dc.contributor.author | Choi, Byung Ock | - |
dc.contributor.author | Chai, Gyu Young | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Ha, Woo Song | - |
dc.contributor.author | Jirtle, Randy L. | - |
dc.date.accessioned | 2022-12-27T06:11:25Z | - |
dc.date.available | 2022-12-27T06:11:25Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2008-03-07 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/27471 | - |
dc.description.abstract | AIM: To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. (c) 2008 WJG. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.subject | FACTOR-II RECEPTOR | - |
dc.subject | TUMOR-SUPPRESSOR GENE | - |
dc.subject | HAPLO-INSUFFICIENCY | - |
dc.subject | PROMOTES GROWTH | - |
dc.subject | EXPRESSION | - |
dc.subject | CANCER | - |
dc.subject | IGF2R | - |
dc.subject | LOCUS | - |
dc.subject | MOUSE | - |
dc.subject | DEATH | - |
dc.title | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Ki Mun | - |
dc.identifier.doi | 10.3748/wjg.14.1394 | - |
dc.identifier.scopusid | 2-s2.0-41149151320 | - |
dc.identifier.wosid | 000253866400015 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROENTEROLOGY, v.14, no.9, pp.1394 - 1398 | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.title | WORLD JOURNAL OF GASTROENTEROLOGY | - |
dc.citation.volume | 14 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1394 | - |
dc.citation.endPage | 1398 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | FACTOR-II RECEPTOR | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR GENE | - |
dc.subject.keywordPlus | HAPLO-INSUFFICIENCY | - |
dc.subject.keywordPlus | PROMOTES GROWTH | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IGF2R | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | loss of heterozygosity | - |
dc.subject.keywordAuthor | mannose 6-phosphate/insulin-like growth factor 2 receptor | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
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