Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferretsopen access
- Kim, Y.-I.; Yu, K.-M.; Koh, J.-Y.; Kim, E.-H.; Kim, S.-M.; Kim, E.J.; Casel, M.A.B.; Rollon, R.; Jang, S.-G.; Song, M.-S.; Park, S.-J.; Jeong, H.W.; Kim, E.-G.; Lee, O.-J.; Kim, Y.-D.; Choi, Y.; Lee, S.-A.; Choi, Y.J.; Park, S.-H.; Jung, J.U.; Choi, Y.K.
- Issue Date
- Nature Research
- Nature Communications, v.13, no.1
- Journal Title
- Nature Communications
- While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individuals. To further understand differing COVID-19 manifestations in patients of different ages, three age groups of ferrets are infected with SARS-CoV-2. Although SARS-CoV-2 is isolated from all ferrets regardless of age, aged ferrets (≥3 years old) show higher viral loads, longer nasal virus shedding, and more severe lung inflammatory cell infiltration, and clinical symptoms compared to juvenile (≤6 months) and young adult (1?2 years) groups. Furthermore, direct contact ferrets co-housed with the virus-infected aged group shed more virus than direct-contact ferrets co-housed with virus-infected juvenile or young adult ferrets. Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. Thus, SARS-CoV-2-infected aged ferrets highly recapitulate COVID-19 patients with severe symptoms and are useful for understanding age-associated infection, transmission, and pathogenesis of SARS-CoV-2. ? 2022, The Author(s).
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- 자연과학대학 > Division of Life Sciences > Journal Articles
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