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A new cytotoxic guaianolide from Chrysanthemum boreale
- Authors
- Park, Ki Hun; Yang, Min Suk; Park, Moon Ki; Kim, Sang Chan; Yang, Chae Ha; Park, Sook Jahr; Lee, Jong Rok
- Issue Date
- Jan-2009
- Publisher
- ELSEVIER
- Keywords
- Chrysanthemum boreale Makino; Guaianolide; 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide; Cytotoxic activity
- Citation
- FITOTERAPIA, v.80, no.1, pp 54 - 56
- Pages
- 3
- Indexed
- SCIE
SCOPUS
- Journal Title
- FITOTERAPIA
- Volume
- 80
- Number
- 1
- Start Page
- 54
- End Page
- 56
- ISSN
- 0367-326X
1873-6971
- Abstract
- A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound I exhibited cytotoxic activity (IC(50 <=)4 mu g/ml) against all five human cancer cell lines tested. (C) 2008 Elsevier B.V. All rights reserved.
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