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Stereoselective Synthesis of Diverse alpha-Hydroxy-beta-amino Acids and It's Application for Synthesis of Dipeptide Expecting as a Protease Inhibitor
- Authors
- Jang, Sang Hun; Kim, Ju Young; Kim, Min Kyu; Han, Jeong Woo; Park, Ki Hun; Yoon, Yong-Jin; Lee, Sang-Gyeong
- Issue Date
- 20-Jan-2009
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- alpha-Hydroxy-beta-amino acids; Nucleophilic addition; Epoxide ring opening; Eliminative cleavage
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.30, no.1, pp 163 - 171
- Pages
- 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 30
- Number
- 1
- Start Page
- 163
- End Page
- 171
- ISSN
- 0253-2964
1229-5949
- Abstract
- Few alpha-hydroxy-beta-amino acids were synthesized via various nucleophilic addition of the epoxide and followed by stereoselective nucleophilic substitution reaction and eliminative cleavage of the acetal selectively in diacetal compound. One of the synthesized alpha-hydroxy-beta-amino acid reacted with L-leucine methylester to give corresponding dipeptide in good yields.
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