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SARS-CoV 3CL(pro) inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

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dc.contributor.authorRyu, Young Bae-
dc.contributor.authorPark, Su-Jin-
dc.contributor.authorKim, Young Min-
dc.contributor.authorLee, Ju-Yeon-
dc.contributor.authorSeo, Woo Duck-
dc.contributor.authorChang, Jong Sun-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorRho, Mun-Chual-
dc.contributor.authorLee, Woo Song-
dc.date.accessioned2022-12-27T04:18:55Z-
dc.date.available2022-12-27T04:18:55Z-
dc.date.issued2010-03-15-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/25170-
dc.description.abstractQuinone-methide triterpenes, celastrol (1), pristimerin (2), tingenone (3), and iguesterin (4) were isolated from Triterygium regelii and dihydrocelastrol (5) was synthesized by hydrogenation under palladium catalyst. Isolated quinone-methide triterpenes (1-4) and 5 were evaluated for SARS-CoV 3CL(pro) inhibitory activities and showed potent inhibitory activities with IC50 values of 10.3, 5.5, 9.9, and 2.6 mu M, respectively, whereas the corresponding 5 having phenol moiety was observed in low activity (IC50 = 21.7 mu M). As a result, quinone-methide moiety in A-ring and more hydrophobic E-ring assist to exhibit potent activity. Also, all quinone-methide triterpenes 1-4 have proven to be competitive by the kinetic analysis. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleSARS-CoV 3CL(pro) inhibitory effects of quinone-methide triterpenes from Tripterygium regelii-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2010.01.152-
dc.identifier.wosid000275221500017-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.6, pp 1873 - 1876-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume20-
dc.citation.number6-
dc.citation.startPage1873-
dc.citation.endPage1876-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusACUTE RESPIRATORY SYNDROME-
dc.subject.keywordPlus3CL PROTEASE-
dc.subject.keywordPlusCORONAVIRUS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusCELASTROL-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordAuthorSARS-CoV-
dc.subject.keywordAuthor3CL(pro)-
dc.subject.keywordAuthorTripterygium regelii-
dc.subject.keywordAuthorQuinone-methide-
dc.subject.keywordAuthorCelastrol-
dc.subject.keywordAuthorIguesterin-
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