Evaluation of the effects of thiopental, propofol, and etomidate on glomerular filtration rate measured by the use of dynamic computed tomography in dogs

Abstract

Objective-To evaluate the effects of thiopental propofol and etomidate on glomerular filtration rate (GFR) measured by the use of dynamic computed tomography in dogs Animals-17 healthy Beagles Procedures-Dogs were randomly assigned to receive 2 mg of etomidate/kg (n = 5) 6 mg of propofol/kg (7) or 15 mg of thiopental/kg (5) during induction of anesthesia anesthesia was subsequently maintained by isoflurane evaporated in 100% oxygen A 1 mL/kg dosage of a 300 mg/mL solution of iohexol was administered at a rate of 3 mL/s during GFR measurement Regions of interest of the right kidney were manually drawn to exclude vessels and fatty tissues and highlight the abdominal portion of the aorta lohexol clearance per unit volume of the kidney was calculated by use of Patlak plot analysis Results-Mean +/- SD weight-adjusted GFR of the right kidney after induction of anesthesia with thiopental propofol and etomidate was 2 04 +/- 0 36 mL/min/kg 2 06 +/- 0 29 mL/min/kg and 2 14 0 43 mL/min/kg respectively However no significant differences in weightadjusted GFR were detected among the treatment groups Conclusions and Clinical Relevance-Results obtained for the measurement of GFR in anesthetized dogs after anesthetic induction with etomidate propofol or thiopental and maintenance with isoflurane did not differ significantly Therefore etomidate propofol or thiopental can be used in anesthesia-induction protocols that involve the use of isoflurane for maintenance of anesthesia without adversely affecting GFR measurements obtained by the use of dynamic computed tomography in dogs (Am J Vet Res 2011 72 146-151)