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A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides
- Authors
- Han, Sun-Young; Chin, Young-Won
- Issue Date
- Jun-2011
- Publisher
- Taylor & Francis
- Keywords
- Anemarrhena asphodeloides; mangiferin; FLT3; ALK; xanthone
- Citation
- Journal of Enzyme Inhibition and Medicinal Chemistry, v.26, no.3, pp 445 - 448
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Journal of Enzyme Inhibition and Medicinal Chemistry
- Volume
- 26
- Number
- 3
- Start Page
- 445
- End Page
- 448
- ISSN
- 1475-6366
1475-6374
- Abstract
- Bioactivity-guided investigation for the rhizomes of Anemarrhena asphodeloides using the Fms-like tyrosine kinase 3 (FLT3) inhibition assay led to the identification of an active xanthone, mangiferin. Mangiferin was found to inhibit activity of the FLT3 wild type and a mutated form of FLT3 with IC(50) values of 0.7 and 1.2 mu mu M, respectively. Furthermore, this compound was assessed with a small panel of select kinases anaplastic lymphoma kinase (ALK), insulin receptor, and epidermal growth factor receptor) and was also found to be active in ALK assay.</.
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