Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) signalling pathways
- Authors
- Kang, Sang Rim; Park, Kwang Il; Park, Hyeon Soo; Lee, Do Hoon; Kim, Jin A.; Nagappan, Arulkumar; Kim, Eun Hee; Lee, Won Sup; Shin, Sung Chul; Park, Moon Ki; Han, Dae Yong; Kim, Gon Sup
- Issue Date
- 15-Dec-2011
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Citrus aurantium L.; Anti-inflammation; Cyclooxygenase-2; Inducible nitric oxide synthase; Nuclear factor-kappa B (NF-kappa B); Mitogen-activated protein kinase (MAPK)
- Citation
- FOOD CHEMISTRY, v.129, no.4, pp.1721 - 1728
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD CHEMISTRY
- Volume
- 129
- Number
- 4
- Start Page
- 1721
- End Page
- 1728
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/23425
- DOI
- 10.1016/j.foodchem.2011.06.039
- ISSN
- 0308-8146
- Abstract
- Citrus fruits are an abundant source of various flavonoids, which have been used as a traditional herbal medicine in Korea and China. Most flavonoids are known to have anti-oxidant, anti-bacterial and analgesic properties. In this study, it was examined whether flavonoids (nobiletin, naringin and hesperidin) isolated from Korea Citrus aurantium L inhibited the pro-inflammatory mediators including cytokines by blocking nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) signalling in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The flavonoids suppressed mRNA and protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in LPS-induced macrophages. The molecular mechanism was associated with inhibition of the degradation/phosphorylation of I-kappa B-alpha and nuclear translocation of the NF-kappa B p-65 as well as phosphorylation of MAPK by flavonoids. These results suggest that flavonoids have anti-inflammatory effects by suppressing expression of COX-2, iNOS and cytokines by blocking the NF-kappa B and MAPK signalling in RAW 264.7 macrophages. (C) 2011 Elsevier Ltd. All rights reserved.
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