상세 보기
- Kang, Sang Rim;
- Park, Kwang Il;
- Park, Hyeon Soo;
- Lee, Do Hoon;
- Kim, Jin A.;
- ... Lee, Won Sup;
- 외 6명
WEB OF SCIENCE
105SCOPUS
121초록
Citrus fruits are an abundant source of various flavonoids, which have been used as a traditional herbal medicine in Korea and China. Most flavonoids are known to have anti-oxidant, anti-bacterial and analgesic properties. In this study, it was examined whether flavonoids (nobiletin, naringin and hesperidin) isolated from Korea Citrus aurantium L inhibited the pro-inflammatory mediators including cytokines by blocking nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) signalling in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The flavonoids suppressed mRNA and protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in LPS-induced macrophages. The molecular mechanism was associated with inhibition of the degradation/phosphorylation of I-kappa B-alpha and nuclear translocation of the NF-kappa B p-65 as well as phosphorylation of MAPK by flavonoids. These results suggest that flavonoids have anti-inflammatory effects by suppressing expression of COX-2, iNOS and cytokines by blocking the NF-kappa B and MAPK signalling in RAW 264.7 macrophages. (C) 2011 Elsevier Ltd. All rights reserved.
키워드
- 제목
- Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L. on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) signalling pathways
- 저자
- Kang, Sang Rim; Park, Kwang Il; Park, Hyeon Soo; Lee, Do Hoon; Kim, Jin A.; Nagappan, Arulkumar; Kim, Eun Hee; Lee, Won Sup; Shin, Sung Chul; Park, Moon Ki; Han, Dae Yong; Kim, Gon Sup
- 발행일
- 2011-12-15
- 유형
- Article
- 저널명
- Food Chemistry
- 권
- 129
- 호
- 4
- 페이지
- 1721 ~ 1728