MRI features in a canine model of intracerebral hemorrhage

Abstract

Intracerebral hemorrhage (ICH) is common and particularly lethal stroke subtype. The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI) in a canine model of ICH. ICH was induced by autologous blood injection and collagenase injection in four healthy beagle dogs. T1 and T2-weighted imaging of the brain was performed on 3 T and 7 T MR systems at 1 day after induction of ICH. In the acute stage of canine ICH, hemorrhagic lesions were characterized by hypointense on T2-weighted images, but the signal intensity of corresponding lesions was variable on T1-wieighted images. Abnormal lesions of ICH were more evident at 7 T compared to 3 T. This study suggests that MRI may be a reliable diagnostic tool during the acute stage of canine ICH. ? 2012 Springer Science+Business Media Dordrecht.