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Inhibitory Effects of Chicken Egg Yolk Antibody on Infection of Escherichia coli in MacrophageInhibitory Effects of Chicken Egg Yolk Antibody on Infection of Escherichia coli in Macrophage
- Other Titles
- Inhibitory Effects of Chicken Egg Yolk Antibody on Infection of Escherichia coli in Macrophage
- Issue Date
- 2012
- Publisher
- 경상국립대학교 농업생명과학연구원
- Keywords
- Egg yolk immunoglobulin (IgY); Escherichia coli; Infection; Prevention; Egg yolk immunoglobulin (IgY); Escherichia coli; Infection; Prevention
- Citation
- 농업생명과학연구, v.46, no.2, pp 107 - 114
- Pages
- 8
- Indexed
- KCI
- Journal Title
- 농업생명과학연구
- Volume
- 46
- Number
- 2
- Start Page
- 107
- End Page
- 114
- ISSN
- 1598-5504
2383-8272
- Abstract
- The present study evaluated the potential use of immunoglobulin prepared from egg yolk of chickens immunized with Escherichia coli K88 (IgY-Ec) in the control of E. coli K88 infection in RAW 264.7 murine macrophage. The binding activity of IgY-Ec against E. coli K88 surface protein was more specific and increased than control IgY. In infection assay of E. coli in macrophage, the specific IgY-Ec to E. coli K88 remarkably inhibited the phagocytic activity comparing to nonspecific IgY (p<0.001). In adherence assay, bacterial adhesion on macrophage cells was definitely reduced by preincubation of IgY-Ec compared with nonspecific IgY (p<0.05). These findings suggested that IgY-Ec have the protective effects against pathogens and IgY-based diets may have potential benefits for preventing or treating various infections in domestic animals.
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