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Radiolabeled Benzamide Derivatives for Development of Malignant Melanoma Imaging AgentsRadiolabeled Benzamide Derivatives for Development of Malignant Melanoma Imaging Agents

Other Titles
Radiolabeled Benzamide Derivatives for Development of Malignant Melanoma Imaging Agents
Authors
표아영송보름김희정김동연
Issue Date
2022
Publisher
대한방사성의약품학회
Keywords
Benzamide derivatives; Malignant melanoma; Melanin; Positron emission tomography; Molecular imaging
Citation
대한방사성의약품학회지, v.8, no.1, pp 25 - 31
Pages
7
Indexed
KCI
Journal Title
대한방사성의약품학회지
Volume
8
Number
1
Start Page
25
End Page
31
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/2256
ISSN
2384-1583
Abstract
Malignant melanoma has an aggressive nature and high metastatic potential that result in one of the highest cancer mortality rates. Over the past three decades, primary and metastatic melanoma incidence has rapidly increased. The recent advances in diagnostic technology have shown promise, but there is still an enormous need for specific detection methods to diagnose malignant melanoma. Positron emission tomography can visualize a particular biomarker of malignant melanoma and promise a noninvasive image of micrometastases. However, the development of PET radiopharmaceuticals remains necessary for diagnosing malignant melanoma by using positron emission tomography. In this review, the history and a general overview of PET radionuclide labeled benzamide derivatives, including their radiosynthesis, in vivo characterization, and evaluation, are provided as imaging agents for malignant melanoma.
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