Pyrene-imidazolium complexed graphene for the selective fluorescent detection of G-quadruplex forming DNA

Abstract

A unique system has been developed for quantifying G-quadruplex forming DNA down to picomolar levels for future applications in telomeric assessment. Pyrene-imidazolium captured in high amounts on the surface of reduced graphene oxide shells allows specific DNA sequence detection by complex formation resulting in release and fluorescence enhancement of pyrene-imidazolium.