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Flavonoids as receptor tyrosine kinase FLT3 inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chin, Young-Won | - |
| dc.contributor.author | Kong, Jae Yang | - |
| dc.contributor.author | Han, Sun-Young | - |
| dc.date.accessioned | 2022-12-27T00:35:50Z | - |
| dc.date.available | 2022-12-27T00:35:50Z | - |
| dc.date.issued | 2013-03 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/20751 | - |
| dc.description.abstract | The Fms-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase, is involved in the proliferation, differentiation and apoptosis of hematopoietic cells. FLT3 is highly overexpressed in acute myeloid leukemia (AML) of the majority of patients. Screening for flavonoids including flavones, flavanones, flavonols, and flavanonols disclosed that luteolin was potent FLT3 enzyme inhibitor. Furthermore, luteolin suppressed cell proliferation in MV4;11 cells with constitutively activated FLT3. (C) 2013 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 3 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Pergamon Press Ltd. | - |
| dc.title | Flavonoids as receptor tyrosine kinase FLT3 inhibitors | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2013.01.049 | - |
| dc.identifier.scopusid | 2-s2.0-84874658824 | - |
| dc.identifier.wosid | 000315331500041 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, v.23, no.6, pp 1768 - 1770 | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
| dc.citation.volume | 23 | - |
| dc.citation.number | 6 | - |
| dc.citation.startPage | 1768 | - |
| dc.citation.endPage | 1770 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | ACUTE MYELOID-LEUKEMIA | - |
| dc.subject.keywordAuthor | Acute myeloid leukemia | - |
| dc.subject.keywordAuthor | FLT3 | - |
| dc.subject.keywordAuthor | Flavonoids | - |
| dc.subject.keywordAuthor | Luteolin | - |
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