Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells
DC Field | Value | Language |
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dc.contributor.author | Han, Min Ho | - |
dc.contributor.author | Lee, Won Sup | - |
dc.contributor.author | Jung, Ji Hyun | - |
dc.contributor.author | Jeong, Jae-Hun | - |
dc.contributor.author | Park, Cheol | - |
dc.contributor.author | Kim, Hye Jung | - |
dc.contributor.author | Kim, GonSup | - |
dc.contributor.author | Jung, Jin-Myung | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Kim, Gi-Young | - |
dc.contributor.author | Ryu, Chung Ho | - |
dc.contributor.author | Shin, Sung Chul | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Choi, Yung Hyun | - |
dc.date.accessioned | 2022-12-27T00:17:36Z | - |
dc.date.available | 2022-12-27T00:17:36Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/20313 | - |
dc.description.abstract | Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy. Evidence suggests that Allium extracts have anti-cancer properties. However, the mechanisms of the anti-cancer activity of A. cepa Linn are not fully elucidated in human cancer cells. In this study, we investigated anti-cancer effects of polyphenols extracted from lyophilized A. cepa Linn (PEAL) in human leukemia cells and their mechanisms. PEAL inhibited cancer cell growth by inducing caspase-dependent apoptosis. The apoptosis was suppressed by caspase 8 and 9 inhibitors. PEAL also up-regulated TNF-related apoptosis-inducing ligand (TRAIL) receptor DR5 and down-regulated survivin and cellular inhibitor of apoptosis 1 (cIAP-1). We confirmed these findings in other leukemic cells (THP-1, 1(562 cells). In addition, PEAL suppressed Akt activity and the PEAL-induced apoptosis was significantly attenuated in Akt-overexpressing U937 cells. In conclusion, our data suggested that PEAL induced caspase-dependent apoptosis in several human leukemic cells including U937 cells. The apoptosis was triggered through extrinsic pathway by up-regulating DR5 modulating as well as through intrinsic pathway by modulating IAP family members. In addition, PEAL induces caspase-dependent apoptosis at least in part through the inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. This study provides evidence that PEAL might be useful for the treatment of leukemia. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | HUMAN HEPATOMA-CELLS | - |
dc.subject | TRAIL | - |
dc.subject | QUERCETIN | - |
dc.subject | CANCER | - |
dc.subject | DEATH | - |
dc.subject | LIGAND | - |
dc.subject | AKT | - |
dc.title | Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Won Sup | - |
dc.contributor.affiliatedAuthor | Kim, Hye Jung | - |
dc.contributor.affiliatedAuthor | Kim, GonSup | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Myung | - |
dc.contributor.affiliatedAuthor | Ryu, Chung Ho | - |
dc.identifier.doi | 10.1016/j.fct.2013.08.085 | - |
dc.identifier.scopusid | 2-s2.0-84884565599 | - |
dc.identifier.wosid | 000329960400050 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.62, pp.382 - 389 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 62 | - |
dc.citation.startPage | 382 | - |
dc.citation.endPage | 389 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | HUMAN HEPATOMA-CELLS | - |
dc.subject.keywordPlus | TRAIL | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | AKT | - |
dc.subject.keywordAuthor | Allium cepa | - |
dc.subject.keywordAuthor | Polyphenols | - |
dc.subject.keywordAuthor | U937 | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | Akt | - |
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