Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
- Authors
- Yu, E.-A.; Cha, C.-N.; Park, E.-K.; Yoo, C.-Y.; Kim, S.; Lee, H.-J.
- Issue Date
- 2014
- Publisher
- Korean Society of Veterinary Science
- Keywords
- Crude extracts; Medicinal plants; Mice; Streptococcus pyogenes; Treatment efficacy
- Citation
- Korean Journal of Veterinary Research, v.54, no.3, pp 189 - 192
- Pages
- 4
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Veterinary Research
- Volume
- 54
- Number
- 3
- Start Page
- 189
- End Page
- 192
- ISSN
- 2466-1384
2466-1392
- Abstract
- This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1: 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20 μg/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4× MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.