이뇨제를 처방한 재발성 전정장애의 임상적 특징과 경과

Abstract

Background and Objectives: Recurrent vestibulopathy (RV) is a clinical syndromeof unknown etiology characterized by multiple episodic vertigo without auditoryor neurological signs or symptoms. The purpose of this study is to investigatethe clinical characteristics and the natural course of RV with diuretics medication. Materials and Methods: During the period January 2008 to December 2010, wereviewed the clinical records of 30 patients diagnosed with RV. All patients weregiven hydrochlorothiazide medication at least 3 months, approached by telephoneand using a questionnaire to make a long term follow-up. The analysis includedage, sex distribution, natural history, pure tone audiometry, caloric response, ageat onset, and the characteristics of vertigo. Results: Median follow-up was 29months (range, 27−37 months). Patients had a mean age at onset of 48.2 yearsand a mean duration of 2.75 years. An obvious female predilection was found,and unilateral caloric paresis (≥25%) was seen in 23.3%. Of the 30 patients,symptoms resolved in 80% but were unchanged in 20%. No patient with RVdeveloped a central nervous system disease or benign paroxysmal positionalvertigo during follow-up. Conclusion: The present study shows that in themajority of cases, vertigo resolved following diuretics medication. In cases of thepatients with severe or disabling recurrent vestibulopathy, the diuretics medicationmay be effective in reducing the frequency of vertigo attacks.