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Upregulation of Human Mammaglobin Reduces Migration and Invasion of Breast Cancer Cells
- Authors
- Koh, Eun-Ha; Cho, Young-Woo; Mun, Yun-Ja; Ryu, Ji Hyeon; Kim, Eun-Jin; Choi, Dae Seob; Maeng, Kook-Young; Han, Jaehee; Kang, Dawon
- Issue Date
- Jan-2014
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Breast cancer; Gene expression; Invasion and metastasis
- Citation
- CANCER INVESTIGATION, v.32, no.1, pp 22 - 29
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- CANCER INVESTIGATION
- Volume
- 32
- Number
- 1
- Start Page
- 22
- End Page
- 29
- ISSN
- 0735-7907
1532-4192
- Abstract
- Little is known about the biological role of human mammaglobin (hMAM) that is considered as a promising marker for breast cancer. Here, we investigated hMAM's role related to migration and invasion of human breast cancer cells (hBCC). Compared to normal cells, hBCC have high MAM mRNA expression levels. Of the hBCC tested, MAM mRNA expression levels were higher in noninvasive than in invasive cells. Overexpression of hMAM in breast cancer cells decreased migration and invasion, whereas knockdown of hMAM increased both. Taken together, these results suggest that metastasis of hBCC could be controlled by hMAM expression levels.
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