Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex
DC Field | Value | Language |
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dc.contributor.author | Badshah, Haroon | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Ahmad, Ashfaq | - |
dc.contributor.author | Ali, Tahir | - |
dc.contributor.author | Yoon, Gwang Ho | - |
dc.contributor.author | Naseer, Muhammad Imran | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T23:04:42Z | - |
dc.date.available | 2022-12-26T23:04:42Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/18923 | - |
dc.description.abstract | Apomorphine, therapeutically used for Parkinson's disease, is a dopamine D1/D2 receptor agonist that has been determined to be a potent antioxidant and to prevent the reaction of free radicals in the brain. Alcohol is a neurotoxic agent that induces neurodegeneration possibly through the generation of free radicals. In this study, we investigated the antioxidant potential of apomorphine upon ethanol-induced neurodegeneration in the cortex of adult rats. Ethanol-induced apoptotic neurodegeneration was measured via the suppression of Bcl-2, the induction of Bax, the release of cytochrome C and the activation of caspase-9 and caspase-3. Moreover, ethanol-induced elevated levels of cleaved PARP-1 indicated exaggerated neuronal DNA damage. Our results demonstrated the neuroprotective effect of apomorphine by reversing the ethanol-induced apoptotic trend as observed by the increased expression of Bcl-2, down regulation of Bax, inhibition of mitochondrial cytochrome C release and inhibition of activated caspase-9 and caspase-3. Moreover, apomorphine treatment further decreased the expression of cleaved PARP-1 to reveal a reduction in ethanol-induced neuronal damage. Immunohistochemical analysis and Nissl staining also revealed neuroprotective effect of apomorphine after ethanol-induced neuronal cell death. In this study, our results indicated that apomorphine at doses of 1 and 5 mg/kg has neuroprotective effects for ethanol-induced neuronal damage. Finally, we can conclude that apomorphine has effective therapeutic potential to protect the brain against ethanol-induced neurotoxicity. (C) 2014 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | INDUCED APOPTOTIC NEURODEGENERATION | - |
dc.subject | CELL-DEATH | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | BRAIN-INJURY | - |
dc.subject | MOUSE-BRAIN | - |
dc.subject | ALCOHOL | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTECTION | - |
dc.title | Apomorphine attenuates ethanol-induced neurodegeneration in the adult rat cortex | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.1016/j.neuint.2014.04.009 | - |
dc.identifier.scopusid | 2-s2.0-84901068755 | - |
dc.identifier.wosid | 000340309600002 | - |
dc.identifier.bibliographicCitation | NEUROCHEMISTRY INTERNATIONAL, v.74, pp.8 - 15 | - |
dc.relation.isPartOf | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.title | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.volume | 74 | - |
dc.citation.startPage | 8 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | INDUCED APOPTOTIC NEURODEGENERATION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | POLY(ADP-RIBOSE) POLYMERASE | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | BRAIN-INJURY | - |
dc.subject.keywordPlus | MOUSE-BRAIN | - |
dc.subject.keywordPlus | ALCOHOL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Apomorphine | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Ethanol | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
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