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Distribution and accumulation of 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles in the tissues of ICR miceopen access
- Authors
- Hue, J.J.; Lee, H.-J.; Nam, S.Y.; Kim, J.-S.; Lee, B.J.; Yun, Y.W.
- Issue Date
- 2015
- Publisher
- Korean Society of Veterinary Science
- Keywords
- 177Lu; Accumulation; Biodistribution; Nanotoxicity; TCL-SPION
- Citation
- Korean Journal of Veterinary Research, v.55, no.1, pp 57 - 60
- Pages
- 4
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Veterinary Research
- Volume
- 55
- Number
- 1
- Start Page
- 57
- End Page
- 60
- ISSN
- 2466-1384
2466-1392
- Abstract
- To investigate kinetics of free 177Lu and 177Lu-labeled thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION), suspensions were intravenously injected into the tail vein of mice at a dose of 5 μCi/mouse or 15 mg/kg body weight, respectively. Free 177Lu radioactivity levels were highest in kidney followed by liver and lung 1 day post-injection. 177Lu-labeled TCL-SPION radioactivity in liver and spleen was significantly higher compared to that of other organs throughout the experimental period (p < 0.05). Radioactivity in blood, brain, and epididymis rapidly declined until 28 days. Based on these results, TCL-SPION could be a safe carrier of therapeutics.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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