A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis
DC Field | Value | Language |
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dc.contributor.author | Cha, Joon-Yung | - |
dc.contributor.author | Kim, Woe-Yeon | - |
dc.contributor.author | Kang, Sun Bin | - |
dc.contributor.author | Kim, Jeong Im | - |
dc.contributor.author | Baek, Dongwon | - |
dc.contributor.author | Jung, In Jung | - |
dc.contributor.author | Kim, Mi Ri | - |
dc.contributor.author | Li, Ning | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Nakajima, Masatoshi | - |
dc.contributor.author | Asami, Tadao | - |
dc.contributor.author | Sabir, Jamal S. M. | - |
dc.contributor.author | Park, Hyeong Cheol | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.contributor.author | Bohnert, Hans J. | - |
dc.contributor.author | Bressan, Ray A. | - |
dc.contributor.author | Pardo, Jose M. | - |
dc.contributor.author | Yun, Dae-Jin | - |
dc.date.accessioned | 2022-12-26T21:33:38Z | - |
dc.date.available | 2022-12-26T21:33:38Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/17089 | - |
dc.description.abstract | YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accumulation under drought and oxidative stresses. Co-overexpression of an IAA-conjugating enzyme reduces IAA levels but drought stress tolerance is unaffected, indicating that the stress-related phenotype is not based on IAA overproduction. YUC6 contains a previously unrecognized FAD-and NADPH-dependent thiol-reductase activity (TR) that overlaps with the FMO domain involved in IAA biosynthesis. Mutation of a conserved cysteine residue (Cys-85) preserves FMO but suppresses TR activity and stress tolerance, whereas mutating the FAD-and NADPH-binding sites, that are common to TR and FMO domains, abolishes all outputs. We provide a paradigm for a single protein playing a dual role, regulating plant development and conveying stress defence responses. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | DEPENDENT THIOREDOXIN REDUCTASE | - |
dc.subject | FLAVIN MONOOXYGENASES | - |
dc.subject | 2-CYS PEROXIREDOXINS | - |
dc.subject | HYDROGEN-PEROXIDE | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | STOMATAL CLOSURE | - |
dc.subject | LEAF SENESCENCE | - |
dc.subject | HEAT-SHOCK | - |
dc.subject | REDOX | - |
dc.subject | ACTIVATION | - |
dc.title | A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Woe-Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Hyun-Jin | - |
dc.identifier.doi | 10.1038/ncomms9041 | - |
dc.identifier.scopusid | 2-s2.0-84940571251 | - |
dc.identifier.wosid | 000360352300003 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.6 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | DEPENDENT THIOREDOXIN REDUCTASE | - |
dc.subject.keywordPlus | FLAVIN MONOOXYGENASES | - |
dc.subject.keywordPlus | 2-CYS PEROXIREDOXINS | - |
dc.subject.keywordPlus | HYDROGEN-PEROXIDE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | STOMATAL CLOSURE | - |
dc.subject.keywordPlus | LEAF SENESCENCE | - |
dc.subject.keywordPlus | HEAT-SHOCK | - |
dc.subject.keywordPlus | REDOX | - |
dc.subject.keywordPlus | ACTIVATION | - |
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