Caffeine prevents D-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ullah, Faheem | - |
dc.contributor.author | Ali, Tahir | - |
dc.contributor.author | Ullah, Najeeb | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T21:26:10Z | - |
dc.date.available | 2022-12-26T21:26:10Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/16949 | - |
dc.description.abstract | D-galactose has been considered a senescent model for age-related neurodegenerative disease. It induces oxidative stress which triggers memory impairment, neuroinflammation and neurodegeneration. Caffeine act as anti-oxidant and has been used in various model of neurodegenerative disease. Nevertheless, the effect of caffeine against D-galactose aging murine model of age-related neurodegenerative disease elucidated. Here, we investigated the neuroprotective effect of caffeine against D-galactose. We observed that chronic treatment of caffeine (3 mg/kg/day intraperitoneally (i.p) for 60 days) improved memory impairment and synaptic markers (Synaptophysin and PSD95) in the D-galactose treated rats. Chronic caffeine treatment reduced the oxidative stress via the reduction of 8-oxoguanine through immunofluorescence in the D-galactose-treated rats. Consequently caffeine treatment suppressed stress kinases p-JNK Additionally, caffeine treatment significantly reduced the D-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNF alpha and IL-1 beta. Furthermore we also analyzed that caffeine reduced cytochrome C, Bax/Bcl2 ratio, caspase-9, caspase-3 and PARP-1 level. Moreover by evaluating the immunohistochemical results of Nissl and Fluro-Jade B staining showed that caffeine prevented the neurodegeneration in the D-galactose-treated rats. Our results showed that caffeine prevents the D-galactose-induced oxidative stress and consequently alleviated neuroinflammation and neurodegeneration; and synaptic dysfunction and memory impairment. Therefore, we could suggest that caffeine might be a dietary anti-oxidant agent and a good candidate for the age-related neurodegenerative disorders. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | DANGGUI-SHAOYAO-SAN | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | ALZHEIMER-DISEASE | - |
dc.subject | MEMORY DEFICITS | - |
dc.subject | MICE | - |
dc.subject | APOPTOSIS | - |
dc.subject | DAMAGE | - |
dc.subject | IMPAIRMENT | - |
dc.subject | IMMUNOCONTENT | - |
dc.subject | DEGENERATION | - |
dc.title | Caffeine prevents D-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.1016/j.neuint.2015.07.001 | - |
dc.identifier.scopusid | 2-s2.0-84947024027 | - |
dc.identifier.wosid | 000365366600014 | - |
dc.identifier.bibliographicCitation | NEUROCHEMISTRY INTERNATIONAL, v.90, pp.114 - 124 | - |
dc.relation.isPartOf | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.title | NEUROCHEMISTRY INTERNATIONAL | - |
dc.citation.volume | 90 | - |
dc.citation.startPage | 114 | - |
dc.citation.endPage | 124 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | DANGGUI-SHAOYAO-SAN | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | ALZHEIMER-DISEASE | - |
dc.subject.keywordPlus | MEMORY DEFICITS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | IMMUNOCONTENT | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordAuthor | D-galactose | - |
dc.subject.keywordAuthor | Caffeine | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Neuroinflammation and neurodegeneration | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.