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Cited 3 time in webofscience Cited 2 time in scopus
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Pretreatment of outer membrane vesicle and subsequent infection with influenza virus induces a long-lasting adaptive immune response against broad subtypes of influenza virusopen access

Authors
Kim, Chang-UngEo, SukyeongLee, PureumKim, Sang-HyunKim, Young SangKim, Doo-Jin
Issue Date
Feb-2022
Publisher
ELSEVIER
Keywords
Outer membrane vesicle; Influenza; Broad immunity; Long-term protection
Citation
MICROBES AND INFECTION, v.24, no.1
Indexed
SCIE
SCOPUS
Journal Title
MICROBES AND INFECTION
Volume
24
Number
1
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1674
DOI
10.1016/j.micinf.2021.104878
ISSN
1286-4579
1769-714X
Abstract
Influenza is an acute respiratory disease and a global health problem. Although influenza vaccines are commercially available, frequent antigenic changes in hemagglutinin might render them less effective or unavailable. We previously reported that modified outer membrane vesicle (fmOMV) provided immediate and robust protective immunity against various subtypes of influenza virus. However, the effect was transient because it was innate immunity-dependent. In this study, we investigated the effects of consecutive administration of fmOMV and influenza virus on the adaptive immune response and longterm protective immunity against influenza virus. When the mice were pretreated with fmOMV and subsequently infected with influenza virus, strong influenza-specific antibody and T cell responses were induced in both systemic and lung mucosal compartments without pathogenic symptoms. Upon the secondary viral challenge at week 4, the mice given fmOMV and influenza virus exhibited almost complete protection against homologous and heterologous viral challenge. More importantly, this strong protective immunity lasted up to 18 weeks after the first infection. These results show that pretreatment with fmOMV and subsequent infection with influenza virus efficiently induces broad and long-lasting protective immunity against various virus subtypes, suggesting a novel antiviral strategy against newly-emerging viral diseases without suitable vaccines or therapeutics. (c) 2021 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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