CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Go, Se-Il | - |
dc.contributor.author | Ko, Gyung Hyuck | - |
dc.contributor.author | Lee, Won Sup | - |
dc.contributor.author | Kim, Rock Bum | - |
dc.contributor.author | Lee, Jeong-Hee | - |
dc.contributor.author | Jeong, Sang-Ho | - |
dc.contributor.author | Lee, Young-Joon | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Ha, Woo Song | - |
dc.date.accessioned | 2022-12-26T20:31:05Z | - |
dc.date.available | 2022-12-26T20:31:05Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15753 | - |
dc.description.abstract | Purpose The present study is to investigate the significance of CD44 variant 9 (CD44v9) expression as a biomarker in primary gastric cancer. Materials and Methods With various gastric tissues, we performed immunohistochemical staining for CD44v9. Results The positive expression rates for CD44v9 in tumor, including adenoma, early gastric cancer (EGC), and advanced gastric cancer (AGO), were higher than those in non-tumor tissues (p=0.003). In addition, the higher expression for CD44v9 was observed as the tissue becomes malignant. In the analysis of 333 gastric cancer tissues, we found that positive expression rates for CD44v9 were higher in the intestinal type or well differentiated gastric cancer than in the diffuse type or poorly differentiated gastric cancer. Interestingly, the positive expression indicated poor prognosis in EGC (5-year survival rate [5-YSR] in stage I, 81.7% vs. 95.2%; p=0.013), but not in AGO (5-YSR in stage II, 66.9% vs. 62.2%; p=0.821; 5-YSR in stage III, 34.5% vs. 32.0%; p=0.929). Moreover, strong positive expression (3+) showed a trend suggesting worse prognosis only in EGO, and it appeared to be associated with lymph node metastasis. Conclusion This study suggests that CD44v9 may be a good biomarker for prognosis prediction and for chemoprevention or biomarker-driven therapies only for EGO. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | HYALURONATE | - |
dc.subject | CELLS | - |
dc.subject | METASTASIS | - |
dc.subject | RECEPTOR | - |
dc.title | CD44 Variant 9 Serves as a Poor Prognostic Marker in Early Gastric Cancer, But Not in Advanced Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Se-Il | - |
dc.contributor.affiliatedAuthor | Lee, Won Sup | - |
dc.contributor.affiliatedAuthor | Lee, Jeong-Hee | - |
dc.contributor.affiliatedAuthor | Lee, Young-Joon | - |
dc.identifier.doi | 10.4143/crt.2014.227 | - |
dc.identifier.scopusid | 2-s2.0-84957604002 | - |
dc.identifier.wosid | 000368215200017 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.48, no.1, pp.142 - 152 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 48 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 152 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002074090 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HYALURONATE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | CD44 variant | - |
dc.subject.keywordAuthor | Biological markers | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordAuthor | Prognosis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.