Dextran sulfate sodium upregulates MAPK signaling for the uptake and subsequent intracellular survival of Brucella abortus in murine macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Reyes, Alisha Wehdnesday Bernardo | - |
dc.contributor.author | Arayan, Lauren Togonon | - |
dc.contributor.author | Simborio, Hannah Leah Tadeja | - |
dc.contributor.author | Hop, Huynh Tan | - |
dc.contributor.author | Min, WonGi | - |
dc.contributor.author | Lee, Hu Jang | - |
dc.contributor.author | Kim, Dong Hee | - |
dc.contributor.author | Chang, Hong Hee | - |
dc.contributor.author | Kim, Suk | - |
dc.date.accessioned | 2022-12-26T20:20:49Z | - |
dc.date.available | 2022-12-26T20:20:49Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 0882-4010 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15691 | - |
dc.description.abstract | Brucellosis is one of the major zoonoses worldwide that inflicts important health problems in animal and human. Here, we demonstrated that dextran sulfate sodium (DSS) significantly increased adhesion of Brucella (B.) abortus in murine macrophages compared to untreated cells. Even without infection, Brucella uptake into macrophages increased and F-actin reorganization was induced compared with untreated cells. Furthermore, DSS increased the phosphorylation of MAPKs (ERK1/2 and p38 alpha) in Brucella-infected, DSS-treated cells compared with the control cells. Lastly, DSS markedly increased the intracellular survival of Brucella abortus in macrophages by up to 48 h. These results suggest that DSS enhanced the adhesion and phagocytosis of B. abortus into murine macrophages by stimulating the MAPK signaling proteins phospho-ERK1/2 and p38 alpha and that DSS increased the intracellular survival of B. abortus by inhibiting colocalization of Brucella-containing vacuoles (BCVs) with the late endosome marker LAMP-1. This study emphasizes the enhancement of the phagocytic and intracellular modulatory effects of DSS, which may suppress the innate immune system and contribute to prolonged Brucella survival and chronic infection. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | RECOGNITION | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTORS | - |
dc.subject | FUSION | - |
dc.title | Dextran sulfate sodium upregulates MAPK signaling for the uptake and subsequent intracellular survival of Brucella abortus in murine macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, WonGi | - |
dc.contributor.affiliatedAuthor | Lee, Hu Jang | - |
dc.contributor.affiliatedAuthor | Kim, Dong Hee | - |
dc.contributor.affiliatedAuthor | Chang, Hong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Suk | - |
dc.identifier.doi | 10.1016/j.micpath.2015.10.024 | - |
dc.identifier.scopusid | 2-s2.0-84964607568 | - |
dc.identifier.wosid | 000369122700010 | - |
dc.identifier.bibliographicCitation | MICROBIAL PATHOGENESIS, v.91, pp.68 - 73 | - |
dc.relation.isPartOf | MICROBIAL PATHOGENESIS | - |
dc.citation.title | MICROBIAL PATHOGENESIS | - |
dc.citation.volume | 91 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 73 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordAuthor | Brucella abortus | - |
dc.subject.keywordAuthor | Dextran sulfate sodium | - |
dc.subject.keywordAuthor | Adhesion | - |
dc.subject.keywordAuthor | Internalization | - |
dc.subject.keywordAuthor | Macrophage | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.