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Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cellsopen access
- Authors
- Yoon, Nal Ae; Jo, Hyun Gun; Lee, Unn Hwa; Park, Ji Hye; Yoon, Ji Eun; Ryu, Jinhyun; Kang, Sang Soo; Min, Young Joo; Ju, Seong-A; Seo, Eun Hui; Huh, In Young; Lee, Byung Ju; Park, Jeong Woo; Cho, Wha Ja
- Issue Date
- 23-Feb-2016
- Publisher
- IMPACT JOURNALS LLC
- Keywords
- tristetraprolin; EMT; Twist1; Snail1; cell migration
- Citation
- ONCOTARGET, v.7, no.8, pp 8931 - 8943
- Pages
- 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- ONCOTARGET
- Volume
- 7
- Number
- 8
- Start Page
- 8931
- End Page
- 8943
- ISSN
- 1949-2553
1949-2553
- Abstract
- Inhibition of epithelial-mesenchymal transition (EMT)-inducing transcription factors Twist and Snail prevents tumor metastasis but enhances metastatic growth. Here, we report an unexpected role of a tumor suppressor tristetraprolin (TTP) in inhibiting Twist and Snail without enhancing cellular proliferation. TTP bound to the AU-rich element (ARE) within the mRNA 3' UTRs of Twist1 and Snail1, enhanced the decay of their mRNAs and inhibited the EMT of cancer cells. The ectopic expression of Twist1 or Snail1 without their 3' UTRs blocked the inhibitory effects of TTP on the EMT. We also observed that TTP overexpression suppressed the growth of cancer cells. Our data propose a new model whereby TTP down-regulates Twist1 and Snail1 and inhibits both the EMT and the proliferation of cancer cells.
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