Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NF kappa B signaling pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Badshah, Haroon | - |
dc.contributor.author | Ali, Tahir | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T20:17:39Z | - |
dc.date.available | 2022-12-26T20:17:39Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2016-04-20 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15534 | - |
dc.description.abstract | Toll-like receptor 4 (TLR4) signaling in the brain mediates autoimmune responses and induces neuroinflammation that results in neurodegenerative diseases, such as Alzheimer's disease (AD). The plant hormone osmotin inhibited lipopolysaccharide (LPS)-induced TLR4 downstream signaling, including activation of TLR4, CD14, IKK alpha/beta, and NF kappa B, and the release of inflammatory mediators, such as COX-2, TNF-alpha, iNOS, and IL-1 beta. Immunoprecipitation demonstrated colocalization of TLR4 and AdipoR1 receptors in BV2 microglial cells, which suggests that osmotin binds to AdipoR1 and inhibits downstream TLR4 signaling. Furthermore, osmotin treatment reversed LPS-induced behavioral and memory disturbances and attenuated LPS-induced increases in the expression of AD markers, such as A beta, APP, BACE-1, and p-Tau. Osmotin improved synaptic functionality via enhancing the activity of pre-and post-synaptic markers, like PSD-95, SNAP-25, and syntaxin-1. Osmotin also prevented LPS-induced apoptotic neurodegeneration via inhibition of PARP-1 and caspase-3. Overall, our studies demonstrated that osmotin prevented neuroinflammation-associated memory impairment and neurodegeneration and suggest AdipoR1 as a therapeutic target for the treatment of neuroinflammation and neurological disorders, such as AD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | NEURODEGENERATION | - |
dc.subject | ADIPONECTIN | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | DEATH | - |
dc.subject | TLR4 | - |
dc.subject | CD14 | - |
dc.subject | INFLAMMATION | - |
dc.subject | RECOGNITION | - |
dc.title | Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NF kappa B signaling pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.1038/srep24493 | - |
dc.identifier.scopusid | 2-s2.0-84964322307 | - |
dc.identifier.wosid | 000374386800001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.6 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | ADIPONECTIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | TLR4 | - |
dc.subject.keywordPlus | CD14 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RECOGNITION | - |
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