Protection efficacy of the Brucella abortus ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Ae Jeong | - |
dc.contributor.author | Moon, Ja Young | - |
dc.contributor.author | Kim, Won Kyong | - |
dc.contributor.author | Kim, Suk | - |
dc.contributor.author | Hur, Jin | - |
dc.date.accessioned | 2022-12-26T20:02:39Z | - |
dc.date.available | 2022-12-26T20:02:39Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15238 | - |
dc.description.abstract | Brucella abortus cells were lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36). Next, the protection efficacy of the lysed fragment as a vaccine candidate was evaluated. Group A mice were immunized with sterile PBS, group B mice were intraperitoneally (ip) immunized with 3 x 10(8) colony-forming units (CFUs) of B. abortus strain RB51, group C mice were immunized ip with 3 x 10(8) cells of the B. abortus vaccine candidate, and group D mice were orally immunized with 3 x 10(9) cells of the B. abortus vaccine candidate. Brucella lipopolysaccharide (LPS)-specific serum IgG titers were considerably higher in groups C and D than in group A. The levels of interleukin (IL)-4, IL-10, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) were significantly higher in groups B-D than in group A. After an ip challenge with B. abortus 544, only group C mice showed a significant level of protection as compared to group A. Overall, these results show that ip immunization with a vaccine candidate lysed by GI24 can effectively protect mice from systemic infection with virulent B. abortus. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN SOC VET SCI | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | BALB/C MICE | - |
dc.subject | RECOMBINANT SALMONELLA | - |
dc.subject | ORAL IMMUNIZATION | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | INFECTION | - |
dc.subject | STRAIN | - |
dc.subject | RB51 | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Protection efficacy of the Brucella abortus ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Suk | - |
dc.identifier.doi | 10.1292/jvms.16-0036 | - |
dc.identifier.scopusid | 2-s2.0-84994236132 | - |
dc.identifier.wosid | 000386746000001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, v.78, no.10, pp.1541 - 1548 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.volume | 78 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1541 | - |
dc.citation.endPage | 1548 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | BALB/C MICE | - |
dc.subject.keywordPlus | RECOMBINANT SALMONELLA | - |
dc.subject.keywordPlus | ORAL IMMUNIZATION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | RB51 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordAuthor | antimicrobial peptide | - |
dc.subject.keywordAuthor | Brucella abortus | - |
dc.subject.keywordAuthor | brucellosis | - |
dc.subject.keywordAuthor | vaccination | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.