Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an A beta(1-42) Mouse Model of Alzheimer's Disease
DC Field | Value | Language |
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dc.contributor.author | Ali, Tahir | - |
dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Rehman, Shafiq Ur | - |
dc.contributor.author | Ahmad, Ashfaq | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T18:32:48Z | - |
dc.date.available | 2022-12-26T18:32:48Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/13461 | - |
dc.description.abstract | Nanomedicine is an emerging research area. In this study, we investigated the neuroprotective efficacy of anthocyanin-loaded polyethylene glycol-gold nanoparticles (PEG-AuNPs) for enhancing the neuroprotective efficacy of anthocyanins in an amyloid beta (A beta)(1-42) mouse model of Alzheimer's disease. We observed that both anthocyaninloaded PEG-AuNPs and anthocyanins treatment (12 mu g/g/day for 14 days) ameliorated memory impairments in the A beta(1-42)-injected mice. However, the anthocyanin-loaded PEG-AuNPs were more effective than free anthocyanins. Anthocyanin-loaded PEG-AuNPs protected pre-and post-synaptic proteins from A beta(1-42)-induced synaptic dysfunction. Interestingly, the anthocyanin-loaded PEG-AuNPs also regulated the p-PI3K/p-Akt/p-GSK3 beta pathway and, as a result, prevented the hyperphosphorylation of tau protein at serines 413 and 404 in the A beta(1-42)-injected mice. Western blot results of cytochrome c, Bax/Bcl2, caspases and poly (ADP-ribose) polymerase-1 expression levels, and immunohistochemical Nissl and Fluoro-Jade B staining also indicated that the anthocyanin-loaded PEG-AuNPs inhibited apoptosis and neurodegeneration in the A beta(1-42)-injected mice. Our results suggest that the conjugation of dietary polyphenolic compounds with gold nanoparticles, such as anthocyanin-loaded PEG-AuNPs, is a novel approach that may represent an important and promising nanomedicine strategy to prevent age-associated neurodegenerative diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | INDUCED OXIDATIVE STRESS | - |
dc.subject | AMYLOID-BETA PEPTIDE | - |
dc.subject | BLOOD-BRAIN-BARRIER | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | IN-VIVO | - |
dc.subject | INDUCED NEUROINFLAMMATION | - |
dc.subject | TAU-HYPERPHOSPHORYLATION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | SYNAPTIC DYSFUNCTION | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.title | Anthocyanin-Loaded PEG-Gold Nanoparticles Enhanced the Neuroprotection of Anthocyanins in an A beta(1-42) Mouse Model of Alzheimer's Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.1007/s12035-016-0136-4 | - |
dc.identifier.scopusid | 2-s2.0-84991098176 | - |
dc.identifier.wosid | 000409039000059 | - |
dc.identifier.bibliographicCitation | MOLECULAR NEUROBIOLOGY, v.54, no.8, pp.6490 - 6506 | - |
dc.relation.isPartOf | MOLECULAR NEUROBIOLOGY | - |
dc.citation.title | MOLECULAR NEUROBIOLOGY | - |
dc.citation.volume | 54 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 6490 | - |
dc.citation.endPage | 6506 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | INDUCED OXIDATIVE STRESS | - |
dc.subject.keywordPlus | AMYLOID-BETA PEPTIDE | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | INDUCED NEUROINFLAMMATION | - |
dc.subject.keywordPlus | TAU-HYPERPHOSPHORYLATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | SYNAPTIC DYSFUNCTION | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Nanomedicine | - |
dc.subject.keywordAuthor | Anthocyanin-PEG-goldnanoparticles | - |
dc.subject.keywordAuthor | Synaptic dysfunction | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
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