Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against A beta(1-42)-induced neuroinflammation and neurodegeneration via the NF-B-K /JNK/GSK3 beta signaling pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Ju | - |
dc.contributor.author | Rehman, Shafiq Ur | - |
dc.contributor.author | Amin, Faiz Ul | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T18:31:58Z | - |
dc.date.available | 2022-12-26T18:31:58Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 1549-9634 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/13408 | - |
dc.description.abstract | Amyloid-beta (A beta(1-42)) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in A beta(1-42)-injected mouse and in vitro models of AD. We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced A beta(1-42)-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-kappa B/p-GSK3 beta pathway in both in vivo and in vitro AD models. However, anthocyanins loaded with PEG-AuNPs were more effective compared to anthocyanins alone. Taken together, these results demonstrate that PEG-coated gold anthocyanins nanoparticles could be a new therapeutic agent in the field of nanomedicine to prevent neurodegenerative diseases such as AD. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | ALZHEIMERS-DISEASE BRAIN | - |
dc.subject | AMYLOID-BETA | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | IN-VIVO | - |
dc.subject | KAPPA-B | - |
dc.subject | RAGE | - |
dc.subject | TAU | - |
dc.subject | APOPTOSIS | - |
dc.subject | RECEPTOR | - |
dc.title | Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against A beta(1-42)-induced neuroinflammation and neurodegeneration via the NF-B-K /JNK/GSK3 beta signaling pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.1016/j.nano.2017.06.022 | - |
dc.identifier.scopusid | 2-s2.0-85028449898 | - |
dc.identifier.wosid | 000414301400015 | - |
dc.identifier.bibliographicCitation | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, v.13, no.8, pp.2533 - 2544 | - |
dc.relation.isPartOf | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.citation.title | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2533 | - |
dc.citation.endPage | 2544 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE BRAIN | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | RAGE | - |
dc.subject.keywordPlus | TAU | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordAuthor | PEG-AuNPs | - |
dc.subject.keywordAuthor | Amyloid beta | - |
dc.subject.keywordAuthor | Anthocyanins | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
dc.subject.keywordAuthor | Neuroinflammation | - |
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