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Skin regeneration effect of the Glycosaminoglycans from Liparis tessellatus eggs
- Authors
- Lee, Jae-Joon; Ticar, Bernadeth F.; Rohmah, Zuliyati; Park, Si-Hyang; Kang, Dawon; Kang, Seok-Joong; Choi, Byeong-Dae
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Liparis tessellatus eggs; Glycosaminoglycans; Tyrosinase inhibition; Fibroblast proliferation
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.105, pp 1369 - 1374
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Volume
- 105
- Start Page
- 1369
- End Page
- 1374
- ISSN
- 0141-8130
1879-0003
- Abstract
- A purified Glycosaminoglycans (GAGs) extract from L tessellatus eggs was enzyme-hydrolyzed and then fractionated with DEAE-Sepharose column chromatography. The fractions were subsequently subjected to skin regeneration effects analysis against skin fibroblast (CCD-986sk) cell lines. Fraction 3 is evidently to have tyrosinase inhibition activity by 20.1% at concentration of 50 mg/mL. DOPA oxidation assay, collagenase inhibition activity assay, fibroblast proliferation assay, and production of type I C-peptide assays were done to further proof the skin regeneration effect of GAGs fractions. Results revealed that fraction 3 has effective skin regeneration activities at a concentration of 200 mg/mL. (C) 2017 Elsevier B.V. All rights reserved.
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