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Cited 4 time in webofscience Cited 7 time in scopus
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Effects of lifetime cumulative ginseng intake on cognitive function in late lifeopen access

Authors
Lho, Silvia KyungjinKim, Tae HuiKwak, Kyung PhilKim, KayoungKim, Bong JoKim, Shin GyeomKim, Jeong LanKim, Tae HyunMoon, Seok WooPark, Jae YoungPark, Joon HyukByun, SeonjeongSuh, Seung WanSeo, Ji YoungSo, YoonseopRyu, Seung-HoYoun, Jong ChulLee, Kyoung HwanLee, Dong YoungLee, Dong WooLee, Seok BumLee, Jung JaeLee, Ju RiJeong, HyeonJeong, Hyun-GhangJhoo, Jin HyeongHan, KyuheeHong, Jong WooHan, Ji WonKim, Ki Woong
Issue Date
24-May-2018
Publisher
BMC
Keywords
Ginseng; Panax; Aged; Cognition; Cohort studies; Longitudinal studies
Citation
ALZHEIMERS RESEARCH & THERAPY, v.10
Indexed
SCIE
SCOPUS
Journal Title
ALZHEIMERS RESEARCH & THERAPY
Volume
10
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/11639
DOI
10.1186/s13195-018-0380-0
ISSN
1758-9193
Abstract
Background: We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-welling population-based prospective cohort of Korean elders. Methods: Community-dwelling elders (N = 6422, mean age = 702 +/- 69 years, education = 80 +/- 5.3 years, female = 56.8%) from the Korean Longitudinal Study on Cognitive Aging and Dementia weie included. Among them, 3918 participants (61.0%) completed the 2-year and 4-year follow-up evaluations. Subjects were categorized according to cumulative ginseng intake at baseline evaluation; no use group, low use (< 5 years) group, and high use (>= 5 years) group One-way analysis of covariance (ANCOVA) was conducted to compare the impact of cumulative ginseng intake on baseline Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet neuropsychological battery total score (CERAD total score) and Mini-Mental State Examination (MMSE) score among the three groups while adjusting for potential covariates. A repeated-measures ANCOVA was performed to investigate the impacts on the changes in CERAD total scores and MMSE scores during the 4 years of follow up. Results: The high use group showed higher CERAD total scores compared to the no use group after controlling for age, sex, education years, socioeconomic status, smoking, alcohol intake, presence of hypertension, stroke history, Geriatric Depression Scale, Cumulative Illness Rating Scale, and presence of the APOE e4 allele (F(2,4762) = 3.978, p = 0.019) The changes of CERAD total score for 2 or 4 years of follow-up did not differ according to the use of ginseng. Conclusions: Cumulative ginseng use for longer than 5 years may be beneficial to cognitive function in late life.
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