조영제용 나노입자 합성을 위한 강건설계 사례

Abstract

A robust design methodology is applied to help establish nanoparticles synthesis method using FeOOH, which ismore economical and patent free than using FeClx. Before this experimental study the between-batch dispersionof the diameter of the synthesized nanoparticles was large due to noise factors. In order to increase the level ofquality reproducibility, we identified the noise factors influencing the variation of the nanoparticle size, selectedcontrol factors and their levels, and conducted a robust design to secure the uniformity quality. The quality ofreproducibility of the thermal decomposition method was found to be improved from less than 50% to 93% byconfirmation experiment. Follow-up experiment was run to transfer the optimal condition of the laboratory to thepilot plant scale.